A Comprehensive Combination of Immune Support Ingredients

Tru Immune Support from TruGen3 provides the well-researched ingredients necessary to keep the immune system healthy.* It is a comprehensive combination of botanicals, vitamins, and other natural substances designed to support immune cell function and promote respiratory health.* No other immune supplement contains this effective and unique combination designed to maintain humoral and innate immunity and lead to optimal health.*

Immune Support & Respiratory Health

Vitamin C and Zinc

Tru Immune Support contains healthful amounts of these two well-known immune-supporting nutrients.* Each of these is foundational to immune health.* For example, a meta-analysis determined that vitamin C was effective at supporting the health of 11,077 people who had the common cold.²* Dietary zinc also is critical for immunity. Even a mild deficiency can lead to weakened immune cell function.²* Studies have found zinc supplementation can support immune health in people encountering wintertime immune system challenges.²*

Astragalus

This botanical found in Tru Immune Support contains high amounts of polysaccharides, flavonoids, multiple trace minerals, and amino acids, all of which boast immune-supporting attributes.²* Astragalus keeps immune cells healthy.* Specifically, it maintains healthy humoral and adaptive immunity, leading to effective production of antibodies, supporting an optimal
CD4+/CD8+ ratio (a balanced ratio is an indication of optimal immune health), and shifting the Th1/Th2 immune response in favor of antiviral actions.^3-6*
Astragalus may also increase the activation of natural killer cells,7 an important part of the body’s innate immune system.* Astragalus stabilizes immunity in cells exposed to the influenza virus.⁸* In animals exposed to the avian influenza virus, astragalus promotes a fast humoralimmune response.⁹* Furthermore, astragalus is involved in the health of respiratory cells,¹⁰ and research has found astragalus supports the lung health of human patients.^11,12 As an antioxidant, it also supports lung health in conditions of oxidative stress.¹³*

EpiCor®**

EpiCor® is a dried fermentate produced from Saccharomyces cerevisiae, an immune-modulatingbaker’s yeast.* There are a number of good human studies showing EpiCor® acts as an antioxidant and supports a healthy immune response during exposure to colds and flus and during pollen season.^14,17* EpiCor® strengthens mucosal immunity and increases levels of salivary secretory immunoglobulin A,14 a substance coating mucosal surfaces that acts like a
shield to stop unwanted substances from entering the body.* EpiCor® increases natural killer cells and supports a healthy inflammatory response.^14,18* Three Generations of Truth in Nutrition

Olive Leaf Extract

Olive leaf extract contains phenolic compounds, especially oleuropein, an antioxidant shown to possess antimicrobial actions and to support a healthy inflammatory response.²* Research suggests that olive leaf reduces infectivity and replication by interacting with the protein of virus
particles, weakening viral actions.¹⁹* It also promotes a healthy immune response by encouraging phagocytosis, the ability of immune cells to engulf invaders,2 and it stimulates the production of natural killer cells.²⁰* A randomized, placebo-controlled study of 32 high school athletes found olive leaf extract supported upper respiratory tract health.²¹21* Tru Immune Support contains olive leaf extract with a generous 16% oleuropein for optimal potency.*

Berberine HCl

Animal studies, cell culture experiments, and use in clinical practice suggest berberine supports a healthy inflammatory response and maintains immunity.* It promotes lung health in animals and the health of human airway cells.^22-24* Berberine also stabilizes the inflammatory response during exposure to allergens.²⁵* Additionally, berberine may be able to weaken bacteria that have formed biofilms,²⁶* the colonization of bacteria in an area of the body or a surface. Biofilm formation protects the bacteria against antimicrobial substances.

N-Acetyl-L-Cysteine

N-Acetyl-L-Cysteine (NAC) is an antioxidant used to provide powerful support to the lungs and respiratory tract due to its ability to break up mucus and clear the respiratory passages.²* Human studies have shown NAC can significantly support immune system health and lung function during cold and flu season.^27,28

Garlic

This botanical may promote immune system health.* One double-blind, placebo-controlled study of 146 participants found that a garlic supplement was able to support immunity from November to February.²⁹* A cell culture study investigated the effects of organosulfur compounds found in
garlic essential oil on SARS-CoV-2.30* Angiotensin-converting enzyme 2 (ACE2) protein in the human body serves as a receptor for SARS-CoV-2.* By blocking ACE2, garlic compounds may support immune health during exposure to this virus.* This is an interesting line of research scientists will hopefully undertake in humans in the future.

Citrus Bioflavonoid Complex

Citrus bioflavonoids are beneficial compounds derived from such fruits as oranges and lemons. Citrus bioflavonoids like hesperidin are able to maintain immunity.^31-32* They work together synergistically with vitamin C to promote optimal health.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
** EpiCor® is a registered trademark of Embria Health Sciences, LLC

References:
1. Douglas RM, et al. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2004 Oct 18 (4):CD000980.
2. Roxas M, Jurenka J. Colds and Influenza: A Review of Diagnosis and Conventional, Botanical, and Nutritional Considerations. Altern Med Rev. 2007 Mar;12(1):25-48.
3. Niu GH, et al. [Effect of Compound Astragalus Recipe on Lymphocyte Subset, Immunoglobulin and Complements in Patients With Myasthenia Gravia]. [Article in Chinese, Abstract in English] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):305-8.
4. Liu ZG, et al. [Effect of Astragalus Injection on Immune Function in Patients With Congestive Heart Failure]. [Article in Chinese, Abstract in English.] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 May;23(5):351-3.
5. Cai XY, et al. [Effects of Radix Astragali Injection on Apoptosis of Lymphocytes and Immune Function in Patients With Systemic Lupus Erythematosus]. [Article in Chinese, Abstract in English.] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 May;26(5):443-5.
6. Mao S, et al. [Modulatory Effect of Astragalus Membranaceus on Th1/Th2 Cytokine in Patients With Herpes Simplex Keratitis]. [Article in Chinese, Abstract in English.] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3.
7. Jiang D, et al. Milkvetch Root Improves Immune Function in Patients With Acute Exacerbation of COPD. Biomed Mater Eng. 2015;26 Suppl 1:S2113-21.
8. Liang Y, et al. Astragalus Membranaceus Treatment Protects Raw264.7 Cells From Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway. Evid Based Complement Alternat Med. 2019 Dec 31;2019:2971604.
9. Kallon S, et al. Astragalus Polysaccharide Enhances Immunity and Inhibits H9N2 Avian Influenza Virus in Vitro and in Vivo. J Anim Sci Biotechnol. 2013 Jun 21;4(1):22.
10. Zhao L, et al. Astragalus Polysaccharides Exerts Anti-Infective Activity by Inducing Human Cathelicidin Antimicrobial Peptide LL-37 in Respiratory Epithelial Cells. Phytother Res. 2018 Aug;32(8):1521-9.
11. Niu HR, et al. [Observation on Effect of Supplementary Treatment by Astragalus Injection in Treating Senile Pulmonary Tuberculosis Patients]. [Article in Chinese, Abstract in English.] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 May;21(5):349-50.
12. Jiang D, et al. Milkvetch Root Improves Immune Function in Patients With Acute Exacerbation of COPD. Biomed Mater Eng. 2015;26 Suppl 1:S2113-21.
13. Shahzad M, et al. The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease. Curr Drug Targets. 2016;17(12):1331-40.
14. Jensen GS, et al. Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study. J Med Food. 2011
Sep;14(9):1002-10.
15. Moyad MA, et al. Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals. J Altern Complement Med. 2010 Feb;16(2):213-8.
16. Moyad MA, et al. Effects of a modified yeast supplement on cold/flu symptoms. Urol Nurs. 2008 Feb;28(1):50-5.
17. Moyad MA, et al. Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial. Adv Ther. 2009 Aug;26(8):795-804.
18. Evans M, et al. A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune models. Evid Based Complement Alternat Med. 2012;2012:973041.
19. Lee-Huang S, et al. Anti-HIV Activity of Olive Leaf Extract (OLE) and Modulation of Host Cell Gene Expression by HIV-1 Infection and OLE Treatment. Biochem Biophys Res Commun. 2003 Aug 8;307(4):1029-37.
20. Magrone T, et al. Olive Leaf Extracts Act as Modulators of the Human Immune Response. Endocr Metab Immune Disord Drug Targets. 2018;18(1):85-93.
21. Somerville V, et al. The Effect of Olive Leaf Extract on Upper Respiratory Illness in High School Athletes: A Randomised Control Trial. Nutrients. 2019 Feb 9;11(2):358. 22. Yan YQ. Anti-influenza Activity of Berberine Improves Prognosis by Reducing Viral Replication in Mice. Phytother Res. 2018 Dec;32(12):2560-7.
23. Wu Y, et al. In Vivo and in Vitro Antiviral Effects of Berberine on Influenza Virus. Chin J Integr Med. 2011 Jun;17(6):444-52.
24. Botwina P, et al. Berberine Hampers Influenza A Replication Through Inhibition of MAPK/ERK Pathway. Viruses. 2020 Mar 21;12(3):344.
25. Kim BY, et al. Berberine reduce allergic inflammation in a house dust mite allergic rhinitis mouse model. Rhinology. 2015 Dec;53(4):353-8.
26. Xie Q, et al. Efficacy of Berberine, an Antimicrobial Plant Alkaloid, as an Endodontic Irrigant Against a Mixed-Culture Biofilm in an in Vitro Tooth Model. J Endod. 2012 Aug;38(8):1114-7.
27. Rasmussen JB, Glennow C. Reduction in Days of Illness After Long-Term Treatment With N-acetylcysteine Controlled-Release Tablets in Patients With Chronic Bronchitis. Eur Respir J. 1988 Apr;1(4):351-5.
28. De Flora S, et al. Attenuation of Influenza-Like Symptomatology and Improvement of Cell-Mediated Immunity With Long-Term N-acetylcysteine Treatment. Eur Respir J. 1997 Jul;10(7):1535-41.
29. P Josling. Preventing the Common Cold With a Garlic Supplement: A Double-Blind, Placebo-Controlled Survey. Adv Ther. Jul-Aug 2001;18(4):189-93.
30. Thuy BTP, et al. Investigation Into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil. ACS Omega. 2020 Mar 31;5(14):8312-20.
31. Saha RK, et al. Glucosyl Hesperidin Prevents Influenza a Virus Replication in Vitro by Inhibition of Viral Sialidase. Biol Pharm Bull. 2009 Jul;32(7):1188-92.
32. Kim HK, et al. Flavanone Glycosides From Citrus Junos and Their Anti-Influenza Virus Activity. Planta Med. 2001 Aug;67(6):548-9.