$46.95
Helps support healthy stress response, immune health, cognitive function, and healthy sleep.
Serving size: 1 softgel
Servings Per Container: 30
TruEase PM Ingredients
Hemp Oil Extract (aerial parts) VESIsorb® HempChoice® BSHOE [standardized to contain 10 mg of cannabidiol (CBD) and 5 mg of betacaryophyllene (BCP)] ………134mg
Melatonin ………. 3mg
OTHER INGREDIENTS: VESIsorb® Colloidal Delivery System [Medium Chain Triglycerides, VEDD (Vitamin E Dimer Derivative), Mono- and Diglycerides, Fatty Acids, Natural Flavors], Aerosil, Capsule Shell [Bovine Gelatin, Glycerin, Annatto (for color), Water].
Hempseed Oil for healthy stress response, immune health, cognitive function, and healthy sleep.
Hempseed oil is rich in several essential fatty acids including the omega-6 fatty acids linoleic acid and gamma linolenic acid as well as omega-3 fatty acids alpha linolenic acid and stearidonic acid. These essential fatty acids have been studied extensively for their roles in supporting optimal skin, heart and neurological health.
Sleepless in 2024: A Novel Way to Support RESTorative Sleep in Patients
Sleep is one of the most critical and frequently overlooked aspects of health. It’s so important that animal research has shown that total sleep deprivation leads to death.1
Furthermore, almost 40% of adults fall asleep inadvertently during the day at least once a month,2 suggesting that much of the population is not receiving RESTorative sleep.
Yet, the connection between poor sleep quantity and quality and health-related symptoms in patients is not always made despite the fact that one-third of U.S. adults report sleeping less than the recommended amount of seven or more hours per night.3,4 The reality is that sleep loss is a widespread problem among patients that may interfere with wellness protocols.
In this article, I’ll address the health consequences and causes of poor sleep and a novel dietary supplement called TruEase PM that provides an effective and safe solution for resolving sleepless nights.
The Health Consequences of Sleep Deprivation
Not getting enough sleep or not sleeping deeply, can lead to mental and physical repercussions.
Mental Health Consequences
• Poor decision-making skills
• Trouble problem solving
• Problems with emotional control and behavior
• Depression
• Suicide
• Risk-taking behavior
• Lack of attention and focus
Physical Health Consequences
• Heart disease
• Kidney disease
• High blood pressure
• Diabetes
• Stroke
• Obesity
Good-quality sleep supports the health of the heart and blood vessels. It also balances the hormones involved in hunger like ghrelin and leptin and not getting enough sleep can lead to increased hunger. Sleep controls blood sugar levels by helping to regulate the body’s insulin metabolism. Furthermore, sleep supports immunity, and lack of sleep can impair the body’s defenses.
Common Reasons Why People Can’t Sleep
So why is sleep deficiency such a common problem? A number of factors play into either not being able to sleep or not getting restful sleep. These include:
• Stress and impaired adrenals can lead to the inability to fall asleep. Sleep deficiency itself can also promote stress due to the activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in increased circulating levels of cortisol.5 It becomes a vicious circle where stress causes sleep loss and the resulting lack of sleep leads to more stress.
• Aging is associated with a decline in sleep duration and quality. This can involve nighttime sleep deficiency and excessive daytime sleepiness.6
• Pain is a common cause of sleep deficiency. More than half of all chronic pain patients suffer from sleep disorders.7
• A drop in melatonin results in problems sleeping. This decline can occur either due to exposure to light at night or the lower melatonin levels produced during aging.8,9
• Altered circadian rhythm, usually from working night shifts, is another culprit behind sleep deficiency and quality.8
• Endocannabinoid tone is involved in sleep quality and quantity. Emerging evidence indicates that the endocannabinoid system plays a role in regulating the circadian sleep-wake cycle.10
A Superior-Quality Sleep Supplement for a Restful Night’s Slumber
Patients seeking a good night’s sleep now have an effective means to enhance their sleep quality and quantity. TruEase PM provides a patent-protected formulation delivering the unmatched therapeutic benefits of cannabidiol (CBD), beta-caryophyllene (BCP), and melatonin powered by the clinically proven VESIsorb® delivery system for maximum absorption and bioavailability.
Cannabidiol (CBD) With Enhanced Bioavailability
Research has shown that CBD benefits sleep in a number of ways including:
1) Improving sleep quality,
2) Reducing occasional stress to promote healthy sleep, and
3) supporting a healthy pain response.
In one study, people who received 160 mg CBD slept more and awakened less during the night compared with the placebo.11 Researchers found similar results when investigating the effects of CBD in 103 patients.12 In this study, CBD improved sleep quality in 66.7% of participants.
CBD works through the endocannabinoid system, which is involved in your body’s own internal clock to promote restful sleep.13 It also calms the central nervous system.12
There’s also a lot of good research in humans showing that CBD can soothe stress. For example, in a double-blind study, 57 healthy males were given oral CBD at doses of 150 mg, 300 mg, or 600 mg or a placebo prior to a public speaking test.14 Compared with the placebo, 300 mg of CBD caused a significant decline in stress during the speech. In another study, 600 mg of CBD before a public speaking test significantly reduced stress, cognitive impairment, and discomfort in speech performance.15
Furthermore, research has shown CBD may support a healthy and normal pain response. In one study, 53% of 97 patients reduced or eliminated opioid use within eight weeks after beginning supplementation with CBD-rich hemp extract.16 Nearly all the patients who used CBD had improved quality of life including improved sleep quality. CBD may also lead to healthy pain responses in nerves.17
CBD needs to be absorbed well in order to work effectively. Normally, CBD has limited oral bioavailability because it’s fat-soluble and has extensive first-pass metabolism. CBD absorption also can vary among different individuals. To overcome these obstacles, the CBD in TruEase PM uses a technology called VESIsorb® shown to improve absorption and bioavailability. A human study found CBD using VESIsorb® technology was 4.4 times more bioavailable than CBD not using the technology.18
Beta-caryophyllene
BCP is a terpene directly responsible for the activation of one of the two primary receptors in the endocannabinoid system. It is common in nature and found in many herbs, and it has FDA generally regarded as safe (GRAS) status.
BCP promotes a healthy inflammatory and pain response.19 Oils like lavender that contain BCP are usually known for their ability to support sleep duration. When combined with these oils, BCP has a soothing effect that can promote relaxation and sleep.20 Absorption of BCP using VESIsorb® technology has been shown to significantly enhance its absorption.21
Melatonin
Melatonin supplementation can support a heathy circadian rhythm, especially during times of melatonin depletion like during aging or when exposed to light at night. In older adults, research shows that 5 mg of melatonin significantly improved sleep efficiency during the day and night, primarily by lengthening the duration of stage 2 non-rapid eye movement sleep and slightly reducing the amount of wakefulness during the night.22
According to the Mayo Clinic, melatonin may be beneficial for:23
• Circadian rhythm sleep disorders in the blind
• Delayed sleep phase (delayed sleep-wake phase sleep disorder)
• Reducing the time it takes to fall asleep, especially in older adults
• Jet lag, including improved alertness and daytime sleepiness
• Shift work disorder
Conclusion
Lack of sleep is a common complaint among patients and may even be an obstacle to the effectiveness of wellness protocols. A highly effective sleep formula known as TruEase PM utilizes a bioavailability-enhancing technology called VESIsorb® as a delivery system for CBD, BCP, and melatonin, three nutrients that can provide our patients with a RESTorative night’s sleep and the renewed health and energy that goes along with it.
Patented VESIsorb® technology is clinically proven to provide up to 6X more bioavilability via multiple PK studies measured in human subjects.† VESIsorb® is the leading delivery system innovation for dramatically improving the bioavailability of poorly absorbed ingredients.
Every TruGen3® product is rigorously tested and formulated with only the highest quality ingredients, including patented VESIsorb® technology, to ensure maximum patient effectiveness.
At TruGen3®, we go to unusually extra lengths to produce every product we offer with only the highest quality, most proven raw materials available anywhere in the world.
REFERENCES
1. Jiang K. Sleep, death, and…the gut? https://news.harvard.edu/gazette/story/2020/06/study-reveals-guts-role-in-causing-death-by-sleep-deprivation/. Published 2020. Accessed 2024.
2. What Are Sleep Deprivation and Deficiency? National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/sleep-deprivation. Published 2022. Accessed 2024.
3. Blackwelder A, Hoskins M, Huber L. Effect of Inadequate Sleep on Frequent Mental Distress. Prev Chronic Dis. 2021;18:E61.
4. Seven or more hours of sleep per night: a health necessity for adults. American Academy of Sleep Medicine. https://aasm.org/seven-or-more-hours-of-sleep-per-night-a-health-necessity-for-adults/. Published 2015. Accessed 2024.
5. Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023;20(1):2243252.
6. Ly S, Naidoo N. Loss of DmGluRA exacerbates age-related sleep disruption and reduces lifespan. Neurobiol Aging. 2019;80:83-90.
7. Duo L, Yu X, Hu R, Duan X, Zhou J, Wang K. Sleep disorders in chronic pain and its neurochemical mechanisms: a narrative review. Front Psychiatry. 2023;14:1157790.
8. Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sci. 2017;173:94-106.
9. Verma AK, Khan MI, Ashfaq F, Rizvi SI. Crosstalk Between Aging, Circadian Rhythm, and Melatonin. Rejuvenation Res. 2023;26(6):229-241.
10. Lavender I, McGregor IS, Suraev A, Grunstein RR, Hoyos CM. Cannabinoids, Insomnia, and Other Sleep Disorders. Chest. 2022;162(2):452-465.
11. Carlini EA, Cunha JM. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol. 1981;21(S1):417s-427s.
12. Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J. 2019;23:18-041.
13. Sanford AE, Castillo E, Gannon RL. Cannabinoids and hamster circadian activity rhythms. Brain Res. 2008;1222:141-148.
14. Linares IM, Zuardi AW, Pereira LC, et al. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Braz J Psychiatry. 2019;41(1):9-14.
15. Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011;36(6):1219-1226.
16. Capano A, Weaver R, Burkman E. Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgrad Med. 2020;132(1):56-61.
17. Costa B, Trovato AE, Comelli F, Giagnoni G, Colleoni M. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2007;556(1-3):75-83.
18. Knaub K, Sartorius T, Dharsono T, Wacker R, Wilhelm M, Schön C. A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb(®) Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects. Molecules. 2019;24(16).
19. Scandiffio R, Geddo F, Cottone E, et al. Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation. Nutrients. 2020;12(11).
20. Galdino PM, Nascimento MV, Florentino IF, et al. The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38(2):276-284.
21. Mödinger Y, Knaub K, Dharsono T, et al. Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb(®) Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS). Molecules. 2022;27(9).
22. Duffy JF, Wang W, Ronda JM, Czeisler CA. High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults. J Pineal Res. 2022;73(1):e12801.
23. Staff MC. Melatonin. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements-melatonin/art-20363071. Published 2023. Accessed 2024.
© 2026 TruGen3. *Douglas Laboratories® is a registered trademark of Atrium Innovations, Inc. and not affiliated with TruGen3®
†This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The peer-reviewed journal, Alternative Therapies in Health and Medicine, recently published the results of a double-blind study comparing the bioavailability of patented CoQsource Bio-Enhanced CoQ10 to that of other bio-enhanced formulations. The study, entitled, “Relative Bioavailability Comparison of Different Coenzyme Q10 Formulations with a Novel Delivery System,” appears in the March/April, 2009 issue, Volume 15, Number 2.
The graph shows a pharmacokinetic study (single oral dose, crossover) in humans comparing VESIsorb® CoQsource® to the same standard Coenzyme Q10 in different formulation demonstrating an increase of absorption in peak blood levels. The relative bioavialiability of a single oral dose of 120mg of CoQ10 was asserted using the AUC. The results showed 622% higher bioavialiability than the oil-based formula and 499% higher bioavialiability than the solubilizate.
The single oral 120 mg does of the VESIorb® – CoQ10 resulted in a peak plasma level of 6.89 μg/mL compared to 2.24 μg/mL achieved with 120 mg of an oil-based formula.
Analysis of the area under the curve revealed the relative bioavailability of VESIsorb® – CoQ10 was up to 622% compared to the other formulations studied.
VESIsorb® vs. Micelles
Micelles are composed of a surfactant or surfactant mixture and the active substance to be solubilized within the center of the micelle. A micelle is like an aggregate of surfactant molecules dispersed in a liquid solution. A surfactant molecule has a hydrophilic part – called “head” – and a hydrophobic part – called “tail”. A typical micelle in an aqueous solution forms an aggregate with the hydrophilic “head” regions in contact with surrounding water (solvent), sequestering the hydrophobic tail regions in the micelle center. In this “hydrophobic tail center,” the active substance is dissolved. A “classical” micelle system does not contain oil and is a surfactant-rich system. If a micelle contains small amounts of oil, they are called “swollen” micelles.
Like micelles, VESIsorb® is an aqueous dispersion. However, the dispersed phase is composed of both surfactant AND oil and belongs, therefore, to the systemic group of micro-emulsions. The dispersed phase of VESIsorb® can be envisioned as nano-droplets composed of an oily core (triglycerides/orange oil/CoQ10) surrounded by a hydrophilic shell (polysorbate/polyglycerol esters). Compared to a micellar system, the VESIsorb® contains lower amounts of surfactant (which is highly desirable) and high amounts of oil (lipophilic core/center where the active substance is dissolved).
Micro-emulsions acting like real solutions are in a thermodynamic equilibrium and thus, cannot be accountable to the classical image of an emulsion. It is a “colloidal” solution with extremely tiny (< 100nm), highly flexible associates.
VESIsorb® vs. Liposomes
Liposomes are vesicles and composed of a phospholipid bi-layer membrane surrounding an aqueous core. Fat-soluble active substances can only be solubilized within the bi-layer membrane, thus the loading capacity is limited and lower compared to VESIsorb®.
