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The peer-reviewed journal, Alternative Therapies in Health and Medicine, recently published the results of a double-blind study comparing the bioavailability of patented CoQsource Bio-Enhanced CoQ10 to that of other bio-enhanced formulations. The study, entitled, “Relative Bioavailability Comparison of Different Coenzyme Q10 Formulations with a Novel Delivery System,” appears in the March/April, 2009 issue, Volume 15, Number 2.
The graph shows a pharmacokinetic study (single oral dose, crossover) in humans comparing VESIsorb® CoQsource® to the same standard Coenzyme Q10 in different formulation demonstrating an increase of absorption in peak blood levels. The relative bioavialiability of a single oral dose of 120mg of CoQ10 was asserted using the AUC. The results showed 622% higher bioavialiability than the oil-based formula and 499% higher bioavialiability than the solubilizate.
The single oral 120 mg does of the VESIorb® – CoQ10 resulted in a peak plasma level of 6.89 μg/mL compared to 2.24 μg/mL achieved with 120 mg of an oil-based formula.
Analysis of the area under the curve revealed the relative bioavailability of VESIsorb® – CoQ10 was up to 622% compared to the other formulations studied.
VESIsorb® vs. Micelles
Micelles are composed of a surfactant or surfactant mixture and the active substance to be solubilized within the center of the micelle. A micelle is like an aggregate of surfactant molecules dispersed in a liquid solution. A surfactant molecule has a hydrophilic part – called “head” – and a hydrophobic part – called “tail”. A typical micelle in an aqueous solution forms an aggregate with the hydrophilic “head” regions in contact with surrounding water (solvent), sequestering the hydrophobic tail regions in the micelle center. In this “hydrophobic tail center,” the active substance is dissolved. A “classical” micelle system does not contain oil and is a surfactant-rich system. If a micelle contains small amounts of oil, they are called “swollen” micelles.
Like micelles, VESIsorb® is an aqueous dispersion. However, the dispersed phase is composed of both surfactant AND oil and belongs, therefore, to the systemic group of micro-emulsions. The dispersed phase of VESIsorb® can be envisioned as nano-droplets composed of an oily core (triglycerides/orange oil/CoQ10) surrounded by a hydrophilic shell (polysorbate/polyglycerol esters). Compared to a micellar system, the VESIsorb® contains lower amounts of surfactant (which is highly desirable) and high amounts of oil (lipophilic core/center where the active substance is dissolved).
Micro-emulsions acting like real solutions are in a thermodynamic equilibrium and thus, cannot be accountable to the classical image of an emulsion. It is a “colloidal” solution with extremely tiny (< 100nm), highly flexible associates.
VESIsorb® vs. Liposomes
Liposomes are vesicles and composed of a phospholipid bi-layer membrane surrounding an aqueous core. Fat-soluble active substances can only be solubilized within the bi-layer membrane, thus the loading capacity is limited and lower compared to VESIsorb®.
