TruDerma Health

$29.98

TruDerma Health, formulated Dr. Justin Vujevich, MD, FAAD, Dermatologist, is the first supplement that combines clinically researched vitamins and minerals to support normal skin cell change and healthy skin. †   Niacinamide, Biotin, Selenium, and Vitamin D have been utilized at clinically studied dosages to support the skin within the body. † Niacinamide specifically, demonstrated a 23% reduction in new skin cell changes. † (1) Vitamin C supports the synthesis of collagen and acts as an inhibitor after ultraviolet light exposure. †   In addition to formulating TruDerma Health, Dr. Vujevich also conducted various clinical trials on specific ingredients that are used in this formula.

† Chen AC, Martin AJ, Choy B et al. A phase 3 randomized trial of nicotinamide for skin cancer chemoprevention. N Engl J Med 2015:373;1618-1623.

TruGen3’s® TruDerma Health, exclusively formulated by Dr. Justin Vujevich, MD, FAAD, Dermatologist, is the first supplement that combines clinically researched vitamins and minerals to support skin cell repair and the maintenance of healthy skin.

While skin precaution measures and regular use of sunscreen help in the prevention of skin cancer, patients frequently asked if there is anything else they can do in terms of skin cancer prevention?

TruDerma Health® is the first supplement that combines essential skin health vitamins, antioxidants, and niacinamide, which has been shown in clinical trials to reduce new skin cancer formation, into one affordable product.

DISCUSSION

Niacinamide is the physiologically active, water-soluble amide form of niacin (vitamin B3). Niacinamide is a precursor to niacinamide adenine dinucleotide (NAD) and niacinamide adenine dinucleotide phosphate (NADP). NAD and NADP support cellular energy production and act as coenzymes for biochemical reactions in the body. Niacinamide has been shown to maintain the skin through its ability to inhibit physiological mediators that play a role in ultraviolet radiation-induced DNA damage. † (1) In a double-blinded controlled trial, patients received oral niacinamide 500mg or placebo twice a day for four months. Niacinamide supplementation resulted in a 35% reduction in skin damage caused by UV sunlight exposure compared to the placebo group. † (2) A one-year, clinical trial of 386 patients demonstrated a 23% reduction in new skin cancers in patients whom took 500mg of niacinamide twice a day. † (3)

Biotin, also known as vitamin H and coenzyme R, is a cofactor that is paramount to several enzymes involved in carbohydrate metabolism, fatty-acid synthesis and protein formation. A biotin deficiency may lead to various skin diseases. Biotin supplementation demonstrated increased hair growth and healthy skin in infants with biotin deficiency. † (4) (5)

Vitamin D assumes a critical role in the proper functioning of the body. Our sources of vitamin D include the skin after ultraviolet exposure and our diet. Due to the dangers of ultraviolet exposure, the U.S. Branch of Health and Human Services and the World Health Organization strongly encourage obtaining vitamin D through diet and supplementation to ensure adequate vitamin D status. Supplementing with vitamin D may eliminate unnecessary sun exposure as the main source for vitamin D synthesis.

In addition to sun exposure, the body is constantly threatened by damage created from normal oxygen metabolism, and by other chemical reactions. Selenium and zinc are two basic trace elements that provide protection against reactive oxygen species such as free radicals, peroxides, and lipid peroxides by means of their strong antioxidant activity. Selenium is a cofactor for glutathione peroxidase (GPX). The selenium-glutathione peroxidase pathway protects against damage to cellular components. Animal and human studies have found that oral selenium built up assurance against ultraviolet-induced damage to skin cells. † (6,7) Zinc’s cell reinforcement properties support the removal of free oxygen radicals in the body produced after-ultraviolet exposure. † (8)

Vitamin C is among the most powerful antioxidants in humans. Vitamin C is required for the synthesis of collagen and glycosaminoglycans which are the structural components of all connective tissues, for example, skin, tendons, joint cartilage, bone, and blood vessels. In the skin, vitamin C is an effective inhibitor of the generation of reactive oxygen species, particularly after ultraviolet light exposure. † (9)

FORMULA (#5012)

Supplement Facts Serving Size 2 tablets

Vitamin C (as ascorbic acid)………………………………………………………………..250 mg
Vitamin D (as cholecalciferol)……………………………………………………………..20 mcg
Vitamin E (as Natural mixed tocopherols)…………………………………………..67 mg
Thiamin (as thiamin HCl)…………………………………………………………………….10 mg
Riboflavin (as riboflavin 5-phosphate)………………………………………………..10 mg
Niacin (as niacinamide)……………………………………………………………………….1,000 mg
Vitamin B6 (as pyridoxal 5-phosphate)………………………………………………..10 mg
Folate (as Folic Acid)…………………………………………………………………………….400 mcg
Vitamin B12 (as cyanocobalamin & methylcobalamin)…………………………250 mcg Biotin……………………………………………………………………………………………………3,000 mcg
Pantothenic Acid (as d-calcium pantothenate)……………………………………..50 mg Calcium…………………………………………………………………………………………………190 mg
Zinc (as OptiZinc® zinc monomethionine)……………………………………………..15 mg
Selenium (as L-selenomethionine)………………………………………………………..100 mcg

Other Ingredients: calcium carbonate, microcrystalline cellulose, film coat [hypromellose, polydextrose, titanium dioxide (for color), riboflavin (for color), magnesium silicate, spirulina extract (for color), main chain triglycerides, peppermint oil], stearic acid, croscarmellose sodium, silica, rice seed/bran extract and sunflower oil.

SUGGESTED USE

As a dietary supplement, adults take 1 tablet two times per day or as directed by your healthcare professional for support of maximum skin health†

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES
  1. Sujana D, Halliday GM, Damian D. Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin. Carinogenesis 2013;34: 1144-49.
  2. Surjana D. Halliday GM, Martin AJ et al. Oral Nicotinamide reduces actinic keratoses in phase II double- blinded randomized controlled trials. J Invest Dermatol 2012;132:1497-1500.
  3. Chen AC, Martin AJ, Choy B et al. A phase 3 randomized trial of nicotinamide for skin cancer chemoprevention. N Engl J Med 2015:373;1618-1623.
  4. Williams ML, Packman S, Cowan MJ. Alopecia and periorificial dermatitis in biotin-responsive multiple carboxylase deficiency. J Am Acad Dermatol 1983;9:97-103.
  5. Wolf B, Feldman GL. The biotin-dependent carboxylase deficiencies. Am J Hum Genet 1982;34: 699-716.
  6. Stewart M, Camerson GS, Pence BC. Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture. J Invest Dermatol 1996;106: 1086-89.
  7. McKenzie RC. Selenium, ultraviolet radiation and the skin. Clin Exp Dermatol 2000;25:631-36.
  8. Abdel-Mageed AB, Oehme FW. A review of the biochemical roles, toxicity and interactions of zinc, copper and iron: I. Zinc. Vet Hum Toxicol 1990;32:34-39.
  9. Keller, K, Fenske N. Uses of vitamins A, C, and E and related compounds in dermatology: A review. J Am Acad Dermatol 1998;39:611-25.

Case Study

TruGen Case Study Vujevich copy

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